Bioactive Vitamin B Complex: Essential with MTHFR Mutation

Top Bioactive B Complex Vitamins

Explore how MTHFR mutation influences your health and why a bioactive Vitamin B complex is crucial for methylation support.

Have you ever wished there was a magic pill that could cure all your health concerns? Well, while there may not be a single pill that can address every ailment, there is growing evidence that a specific combination of vitamins known as Bioactive Vitamin B Complex can provide tremendous support for a wide range of health issues.

One such combination is the bioactive vitamin B complex, which has shown promising results in supporting various conditions, including high blood pressure, insomnia, depression, anxiety, and restless leg syndrome. But what makes this combination of B vitamins so special?

It all comes down to a key genetic variation called the MTHFR mutation. This genetic variation affects the body's ability to process certain forms of vitamin B, particularly folate and B12. When these vital vitamins are not properly metabolized, it can lead to various health concerns.

However, by supplementing with bioactive B vitamins, which are in forms that are easily utilized by the body, individuals with the MTHFR mutation can support optimal methylation, a vital process for DNA synthesis, neurotransmitter production, and detoxification. This targeted supplementation can help mitigate the health concerns associated with this genetic variation.

In this article, we will compare the top bioactive vitamin B complex supplements on the market, including Life Extensions BioActive Complete B-Complex, Thorne B Complex #6, Pure Encapsulations B-Complex Plus, and Quicksilver Scientific's Liquid Multivitamin Supplement with Bioactive B Vitamins, Vitamin D3, Vitamin C, E + K, and Antioxidants. We will consider factors such as pricing, quality, certifications, and the specific dosages of ingredients, including how much you need to take daily.

Many B Vitamins are found in plants but not all

Key Takeaways:

• The MTHFR mutation affects the body's ability to process vitamin B, leading to a range of health concerns.

• Supplementing with bioactive B vitamins can support optimal methylation and mitigate the health concerns associated with the MTHFR mutation.

• Life Extensions BioActive Complete B-Complex, Thorne B Complex #6, Pure Encapsulations B-Complex Plus, and Quicksilver Scientific's Liquid Multivitamin Supplement are top options to consider for bioactive vitamin B complex supplementation.

• Factors such as pricing, quality, certifications, and specific dosages of ingredients should be considered when choosing a supplement.

• Consulting with a healthcare professional is recommended to determine the most suitable option for your individual needs.

Understanding MTHFR Gene Mutation and Its Impact on Health

The MTHFR mutation is a specific alteration in the MTHFR gene that can lead to decreased enzyme activity. This genetic variation may result in reduced ability to convert dietary and supplemental folate (folic acid) into the active form, known as 5-methyltetrahydrofolate (5-MTHF). The reduced activity of the MTHFR enzyme can have implications for several bodily processes.

Common Health Concerns Associated with MTHFR Variations

Individuals with MTHFR variations may experience various health concerns as a result of impaired folate metabolism. These concerns may include:

• Cardiovascular issues

• Neurological disorders

• Pregnancy complications

• Mental health conditions

Understanding and managing MTHFR mutations are important for individuals seeking to optimize their health and well-being.

The Role of Homocysteine Levels in MTHFR Mutation

Individuals with MTHFR mutations may also have elevated levels of homocysteine, an amino acid that can contribute to cardiovascular and neurological issues when present in high concentrations. Homocysteine levels are affected by the MTHFR mutation due to its essential role in the folate-dependent methylation cycle.

Managing optimal homocysteine levels through appropriate supplementation is key to mitigating the potential health risks associated with the MTHFR mutation.

Exploring the Benefits of Bioactive B Vitamins for Methylation Support

Bioactive B vitamins, particularly folate and B12, play vital roles in supporting proper methylation and overall cellular health. Folate, also known as vitamin B9, is essential for DNA synthesis and repair, ensuring the integrity and stability of our genetic material. It is also involved in the metabolism of homocysteine, an amino acid that, when elevated, can increase the risk of cardiovascular disease. Additionally, folate is crucial for the production of red blood cells, which carry oxygen throughout the body.

B12, or cobalamin, contributes to DNA formation, red blood cell production, and the functioning of the nervous system. It works closely with folate in the process of DNA synthesis, promoting the methylation of DNA and regulating gene expression. B12 deficiency can lead to anemia, neurological symptoms, and impaired cognitive function.

Together, folate and B12 are essential for the methylation process, which plays a critical role in numerous biological pathways. Methylation is involved in regulating gene expression, detoxification, neurotransmitter synthesis, histone modification, and immune function. Adequate levels of bioactive B vitamins are necessary to support optimal methylation and overall health.

One way to ensure sufficient intake of bioactive B vitamins is through supplementation. There are several brands offering products that contain bioactive B vitamins in their active forms. Let's compare three popular options: Life Extensions BioActive Complete B-Complex, Thorne Basic B Complex, and Pure Encapsulations B-Complex Plus, to help you choose the most suitable supplement for your needs.

Table: Comparison of Bioactive B Vitamin Supplements

As seen in the comparison table, all three supplements are of high quality and adhere to Good Manufacturing Practices (GMP). However, there is a small difference in pricing, with Thorne Basic B Complex #6 being the most expensive option. When it comes to dosage, Thorne Basic B Complex and Pure Encapsulations B-Complex Plus require only one capsule per day, while Life Extensions BioActive Complete B-Complex recommends a daily dose of two capsules.

Ultimately, the choice of supplement depends on your specific needs, preferences, and budget. Consulting with a healthcare professional or a registered dietitian can help determine the most suitable option for you. It is important to prioritize high-quality bioactive B vitamins to support optimal methylation and overall health.

Nutrigenomics and Personalized Nutrition for MTHFR Variants

Nutrigenomics is a fascinating field that examines how our unique genetic variations influence our nutrient needs. For individuals with MTHFR variants, understanding these specific nutrient requirements becomes even more crucial. MTHFR variants impact the body's ability to process certain nutrients, such as folate and B12, which are essential for overall health and well-being.

How Genetic Variations Influence Nutrient Needs

Genetic variations, such as MTHFR variants, can affect the body's ability to convert and utilize specific nutrients. In the case of MTHFR mutations, individuals may have difficulty converting folate and B12 into their active forms, which are necessary for various biological processes. As a result, these individuals may require higher levels of bioactive folate and B12 to support their unique nutrient needs.

The Importance of Bioavailability in Nutritional Supplements

Bioavailability refers to how well a nutrient is absorbed and utilized by the body. For individuals with MTHFR variants, choosing nutritional supplements with high bioavailability is essential. This ensures that the body can effectively absorb and utilize the bioactive forms of folate and B12, bypassing any conversion issues caused by the variant.

It's important to note that not all supplements are created equal when it comes to bioavailability. Some formulations may use inactive forms of folate and B12, which may not be as readily absorbed and utilized by individuals with MTHFR variants. Therefore, selecting supplements that specifically provide bioactive B vitamins is crucial for optimal nutrient utilization and support.

MTHFR Mutation and the importance of Bioactive Vitamin B Complex

Individuals with MTHFR mutations experience challenges in metabolizing folate and B12, making it crucial for them to supplement with a bioactive vitamin B complex. A bioactive B complex contains the active forms of B vitamins that are easily absorbed and utilized by the body, bypassing the impaired conversion process caused by the mutation. By providing bioactive B vitamins, individuals with MTHFR mutations can support optimal methylation and overall health.

When comparing vitamin B complex supplements, it is essential to consider factors such as pricing, quality, certifications, and individual ingredient dosages.

Breaking Down Bioactive B Vitamins: Folate, B6, B12, and Betaine

Bioactive B vitamins, including folate, B6, B12, and betaine, are essential nutrients that play crucial roles in supporting optimal methylation and overall health. Let's explore the individual benefits and functions of these bioactive B vitamins:

The bioactive B vitamins work synergistically, each contributing to different aspects of methylation and overall health. Their combined effects create a powerful support system for optimal cellular function and well-being.

Price, Quality, and Certifications: How to Choose the Right Supplement

When selecting a bioactive B complex supplement, it's essential to consider factors beyond brand preferences. Price, quality, certifications, and dosage recommendations all play vital roles in making an informed choice. By comparing these aspects, individuals can find the best supplement that meets their needs for bioactive B vitamins.

Comparing Cost Efficiency Across Different Bioactive B Complex Brands

Cost efficiency is an important consideration when choosing a bioactive B complex supplement. By comparing the prices of different brands, individuals can find a supplement that offers the best value for their budget. It's important to note that a higher price doesn't always guarantee better quality, so conducting research and comparing options is key.

Understanding Certifications: What Do They Mean for Quality?

Certifications such as Good Manufacturing Practices (GMP) can provide valuable insights into the quality and safety of a supplement. GMP certification ensures that the manufacturing processes comply with stringent standards, ensuring the product is produced in a controlled and consistent manner. Look for supplements that have obtained certifications from reputable organizations to ensure quality and safety.

Deciphering Dosages: How Much of Each Vitamin B Is Necessary?

Dosage recommendations for each vitamin B in a bioactive B complex supplement are crucial to ensure individuals are taking the optimal amount for their specific needs. It is important to follow the recommended daily dosage provided by the supplement manufacturer. Consulting with a healthcare professional can also help determine the appropriate dosage based on individual health conditions and requirements.

Conclusion

After exploring the key findings on bioactive B complexes and their role in supporting individuals with MTHFR mutations, it is evident that these vitamins, including folate, B6, B12, and betaine, are crucial for optimal methylation and overall health. Supplements such as Life Extensions BioActive Complete B-Complex, Thorne Basic B Complex, Pure Encapsulations B-Complex Plus, and Quicksilver Scientific's Liquid Multivitamin Supplement with Bioactive B Vitamins offer viable options for individuals seeking personalized supplementation.

When choosing a supplement, it is important to consider factors such as price, quality, certifications, and dosage recommendations. Comparing the cost efficiency of different brands can help individuals find supplements that provide the best value for their money. Additionally, understanding certifications like GMP can ensure the quality and safety of the supplements being consumed.

Furthermore, deciphering the dosage recommendations for each individual ingredient in the B complex is essential for achieving optimal results. By adhering to the recommended daily intake, individuals can ensure they are receiving the appropriate amount of each vitamin required for their specific needs.

Personalized supplementation is key when addressing the unique nutrient requirements of individuals with MTHFR mutations. By choosing the right bioactive B complex supplement and considering important factors like price, quality, certifications, and dosage recommendations, individuals can support their overall health and well-being.

FAQ

What is MTHFR mutation?

MTHFR mutation is a genetic variation that affects the body's ability to process certain forms of vitamin B, particularly folate and B12.

What health concerns are associated with MTHFR variations?

Common health concerns associated with MTHFR variations include cardiovascular issues, neurological disorders, pregnancy complications, and mental health conditions.

How does homocysteine levels relate to MTHFR mutation?

Homocysteine, an amino acid, is often elevated in individuals with MTHFR mutations and can further contribute to health problems associated with the mutation.

What role do bioactive B vitamins play in methylation support?

Bioactive B vitamins, such as folate and B12, are essential for optimal methylation, DNA synthesis, neurotransmitter production, and detoxification.

How does folate contribute to methylation and cell health?

Folate is crucial for DNA synthesis and repair, red blood cell production, and plays a vital role in various biochemical reactions in the body.

How does B12 contribute to DNA and red blood cell formation?

B12 supports DNA formation, red blood cell production, and contributes to neurological functioning.

How do genetic variations influence nutrient needs?

Genetic variations, such as MTHFR variants, may require certain nutrients like folate and B12 to be provided in their active forms to ensure optimal utilization.

Why is bioavailability important in nutritional supplements?

Bioavailability refers to how well a nutrient is absorbed and utilized by the body. It is crucial for individuals with MTHFR variants to choose supplements with high bioavailability to meet their unique nutrient requirements.

Why is bioactive vitamin B complex important for individuals with MTHFR mutations?

Due to their impaired ability to convert folate and B12 into their active forms, individuals with MTHFR mutations need to supplement with a bioactive vitamin B complex to support optimal methylation and overall health.

What are the bioactive B vitamins?

Bioactive B vitamins include folate, B6, B12, and betaine, all of which play synergistic roles in supporting methylation and overall health.

What is Life Extensions BioActive Complete B-Complex?

Life Extensions BioActive Complete B-Complex is a comprehensive supplement that provides a range of bioactive B vitamins in their active forms to support optimal methylation and overall health.

What is Thorne Basic B Complex?

Thorne Basic B Complex is a bioactive B complex supplement formulated to support cellular energy production, methylation, and overall well-being.

What is Pure Encapsulations B-Complex Plus?

Pure Encapsulations B-Complex Plus is a balanced blend of bioactive B vitamins in their active forms known for strict quality standards and commitment to purity.

What is Quicksilver Scientific's Multivitamin?

Quicksilver Scientific's Multivitamin is a liquid bioactive B blend containing bioactive B vitamins, vitamin D3, vitamin C, vitamin E, vitamin K, antioxidants, and other essential nutrients.

How do I choose the right supplement?

Factors such as price, quality, certifications, and dosage recommendations should be considered when choosing a bioactive B complex supplement.

What is the importance of personalized supplementation?

Personalized supplementation addresses specific nutrient needs and supports optimal health for individuals with MTHFR mutations.

What are the key findings on B-Complexes and MTHFR?

Bioactive B complexes are essential for individuals with MTHFR mutations to support their unique nutrient requirements and optimize methylation and overall health.

What are the final thoughts on the importance of personalized supplementation?

Personalized supplementation is crucial for individuals with MTHFR mutations to address their specific nutrient needs and support optimal health.

Source Links

• https://shop.mindbodygreen.com/products/methylation-support

• https://methyl-life.com/blogs/mthfr/multivitamin-for-mthfr

• https://zahlers.com/products/b-complex

MTHFR…Is This Your Problem?

What is MTHFR?

MTHFR stands for methylenetetrahydrofolate reductase, which is an enzyme that plays a crucial role in processing amino acids and converting folate into its active form. Variations in the MTHFR gene can impact the enzyme's function, potentially leading to health issues or affecting the body's ability to utilize certain nutrients efficiently. These variations have been linked to conditions such as cardiovascular disease, neurological disorders, pregnancy complications, and more. Testing for MTHFR mutations can provide insights into personalized healthcare and guide interventions to support overall well-being.

The Role of MTHFR in Malnutrition

MTHFR It plays a crucial role in converting folate (Vitamin B9) into its active form, which is essential for various biological processes, including DNA synthesis and repair, detoxification, and neurotransmitter synthesis.

Certain genetic variations in the MTHFR gene can lead to reduced enzyme activity, affecting the body's ability to utilize and process folate efficiently. The most well-known variants are C677T and A1298C, which have been associated with decreased enzyme function.

In the context of malnutrition, individuals with MTHFR gene mutations may be at a higher risk of developing nutrient deficiencies, especially folate and other B vitamins. This can impact various aspects of health, including decreased red blood cell production, impaired detoxification capacity, and compromised DNA synthesis and repair.

Furthermore, inadequate folate levels due to MTHFR mutations can also affect neurotransmitter production, potentially leading to mental health issues such as depression, anxiety, and cognitive impairments.

It is important for individuals with MTHFR gene mutations to work closely with healthcare providers to optimize their nutrient intake, potentially through supplementation with methylated forms of folate and B vitamins to mitigate the effects of malnutrition and support overall well-being. Regular monitoring and tailored interventions can help manage the impact of MTHFR mutations on nutritional status and health outcomes.

The Importance of Bioactive B Vitamins in Individuals with MTHFR Polymorphism

Individuals with the MTHFR polymorphism often face challenges in effectively metabolizing B vitamins, particularly folate. This genetic variation can impact the MTHFR enzyme's ability to convert folic acid into its active form, methylfolate, which is essential for numerous biochemical processes in the body.

In such individuals, supplementing with bioactive forms of B vitamins becomes crucial to ensure optimal health. Bioactive B vitamins, such as methylated forms of folate (5-MTHF) and B12 (methylcobalamin), bypass the need for enzymatic conversion, making them more readily absorbed and utilized by the body.

By providing bioactive forms of B vitamins, individuals with the MTHFR polymorphism can bypass the genetic bottleneck and support essential processes like DNA synthesis, neurotransmitter production, and detoxification. These bioactive B vitamins play a vital role in promoting overall health and well-being in individuals with this genetic variation.

Risk of Homocysteinuria in Individuals with MTHFR Mutations

Individuals with MTHFR mutations may face an increased risk of homocysteinuria, a condition characterized by elevated levels of homocysteine in the blood. Homocysteine is an amino acid produced during the metabolism of methionine, and elevated levels can lead to various health issues.

MTHFR mutations can impair the ability of the MTHFR enzyme to convert homocysteine to methionine, leading to a buildup of homocysteine in the body. This accumulation can increase the risk of cardiovascular disease, neurological disorders, and other health complications.

It is essential for individuals with MTHFR mutations to work closely with healthcare providers to monitor their homocysteine levels and implement interventions to manage them effectively. This may involve dietary modifications, supplementation with vitamins such as B vitamins, and other personalized strategies to mitigate the risk of homocysteinuria and its associated health concerns.

MTHFR Mutation and Resistant High Blood Pressure

Individuals with the MTHFR gene mutation may face challenges in managing high blood pressure effectively. The MTHFR gene provides instructions for producing an enzyme crucial for processing amino acids. Mutations in this gene can lead to decreased enzyme activity, affecting various bodily functions, including blood pressure regulation.

Resistant high blood pressure, a condition where blood pressure remains high despite medication and lifestyle changes, can be particularly challenging for those with an MTHFR gene mutation. Research suggests a potential link between MTHFR mutations and hypertension, although the exact mechanisms are still under investigation.

For individuals with both the MTHFR mutation and resistant high blood pressure, personalized treatment approaches are essential. Consulting healthcare providers, such as genetic counselors and cardiologists, can help in designing effective management strategies tailored to individual genetic makeup and health needs. Lifestyle modifications, dietary changes, and alternative treatment options may complement conventional therapies to better control blood pressure levels and improve overall health outcomes.

For more information on the MTHFR be sure to log into M. D.IVA Biohacking on YouTube or your favorite podcast provider.

WITH ALL THE CONFLICTING INFO…WHICH DIET IS BEST?

LET’S FIRST START WITH THE BASICS

In the pursuit of optimal health and well-being, the significance of tailored nutrition for women cannot be overstated. From vital micronutrient requirements to effective dietary approaches and empowering superfoods, nourishing the female body goes beyond mere sustenance—it is a powerful act of self-care and empowerment.

In this comprehensive guide, we will first delve into the basics of nutrition. With so many biohacking podcasts available, though most are male-hosted and focused, I want to step back and start from the foundation. Most podcasts are deep in the trenches which is great for seasoned biohackers. I desire to see those who are brand new to this world really embrace their potential and see just how amazing they can feel.

Fundamentals of Macronutrients and Micronutrients

Understanding the basics of macronutrients and micronutrients is crucial for maintaining optimal health as well as hormonal balance. Let’s explore the fundamentals of these essential nutrients, providing you with the knowledge to make informed choices about what goes into your body.

Macronutrients:

1. Carbohydrates: Carbohydrates come in two forms: simple and complex. Simple carbohydrates, found in fruits and refined sugars, provide quick energy bursts. On the other hand, complex carbohydrates, present in whole grains, legumes, and vegetables, offer sustained energy and are rich in fiber, aiding digestion and promoting satiety.

   1. Energy Source: Carbohydrates are the body's primary source of energy. When consumed, they are broken down into glucose, which fuels various bodily functions and activities.

   2. Brain Function: The brain relies heavily on glucose for optimal function, making carbohydrates essential for cognitive performance unless burning ketones.

2. Proteins: Proteins are the building blocks of life. They are crucial for the repair and maintenance of tissues, muscle development, and the production of enzymes and hormones. Sources include beef, poultry, fish, eggs, beans, tofu, and many other animal sources.

   1. Tissue Repair and Growth: Proteins are made up of amino acids, the building blocks of tissues. They play a crucial role in repairing and maintaining tissues, supporting muscle growth, and ensuring the proper functioning of organs.

   2. Enzyme Production: Many enzymes, that facilitate chemical reactions in the body, are proteins. Enzymes are involved in processes like digestion, metabolism, and DNA replication.

3. Fats: Contrary to the misconception that fats are entirely bad, they play a vital role in your health. Fats, such as those found in meat, dairy, eggs, avocados, nuts, seeds, and olive oil, are essential for brain function, hormone production, and nutrient absorption. Erase the script that fats are bad.

   1. Cellular Structure: Fats are integral components of cell membranes, contributing to the structure and fluidity of cells.

   2. Hormone Production: Certain fats are precursors to hormones. For example, omega-3 fatty acids play a role in the production of hormones that regulate blood clotting, inflammation, and contraction of artery walls.

Micronutrients:

1. Vitamins: Vitamins are organic (contain carbon) compounds that support various bodily functions. Each vitamin has a unique role, from boosting immunity (vitamin C) to maintaining healthy skin (vitamin E). Biochemical processes in the body require various vitamins to actually carry out the process.

   • Vitamin A: Essential for vision, immune function, and skin health.

   • Vitamin C: A powerful antioxidant that supports the immune system, collagen synthesis, and wound healing.

   • Vitamin D: Crucial for calcium absorption, promoting bone health, and playing a role in immune function.

   • Vitamin E: An antioxidant that protects cells from damage and supports skin health.Vitamin K: Essential for blood clotting and bone metabolism.

2. Minerals: Minerals are inorganic nutrients vital for bone health, nerve function, and fluid balance. Calcium, magnesium, potassium, and iron are examples of essential minerals. Dairy products, leafy greens, nuts, seeds, and meats can help you meet your mineral requirements.

   • Calcium: Critical for bone and teeth formation, blood clotting, and muscle function.

   • Iron: Involved in the transport of oxygen in the blood and energy metabolism.

   • Magnesium: Supports muscle and nerve function, blood glucose control, and bone health.

   • Potassium: Helps maintain proper fluid balance, nerve signals, and muscle contractions.

3. Trace Elements: Trace elements, such as zinc, copper, and selenium, are required in smaller amounts but are equally crucial for enzyme function and overall well-being. Incorporate seafood, nuts, and whole grains to ensure you're getting these essential trace elements.

   • Zinc: Supports immune function, wound healing, and DNA synthesis.

   • Copper: Involved in the formation of red blood cells and the maintenance of connective tissues.

   • Selenium: Acts as an antioxidant, supporting immune function and thyroid health.

Achieving a balance of macronutrients and micronutrients is key to promoting overall health. Understanding the fundamentals of macronutrients and micronutrients empowers you to make informed choices about your diet. By nourishing your body with a diverse range of nutrients, you're investing in your long-term health and well-being. Remember, it's not about restriction but about creating a sustainable and enjoyable approach to eating that supports your unique needs. Here's to a healthier, more vibrant you!

Dietary Approaches for Female Wellness: Various dietary approaches tailored for women can significantly impact energy levels, mood, and overall health. Whether it's embracing a plant-based diet or incorporating the principles of the Mediterranean diet, the right dietary pattern can lay the foundation for a vibrant and nourished lifestyle.

Common Deficiencies

Deficiencies in essential nutrients can have a significant impact on overall health and well-being. Here are common deficiencies for some key micronutrients and how they may present:

1. Iron Deficiency:

• Symptoms:

  • Fatigue and weakness

  • Pale skin and nails

  • Shortness of breath

  • Difficulty concentrating

• Causes: Inadequate dietary iron, poor iron absorption, or increased iron needs (common in menstruating women).

2. Calcium Deficiency:

• Symptoms:

  • Brittle nails

  • Muscle cramps

  • Weakened bones (increasing the risk of fractures)

• Causes: Insufficient dietary calcium, poor absorption, or conditions affecting calcium metabolism.

3. Vitamin D Deficiency:

• Symptoms:

  • Fatigue

  • Bone pain and muscle weakness

  • Increased susceptibility to infections

• Causes: Inadequate sun exposure, limited dietary sources, or impaired absorption.

4. Vitamin B12 Deficiency:

• Symptoms:

  • Fatigue and weakness

  • Tingling or numbness in extremities

  • Difficulty in maintaining balance

• Causes: Inadequate dietary intake (common in vegetarians and vegans), poor absorption, or certain medical conditions.

5. Vitamin C Deficiency (Scurvy):

• Symptoms:

  • Fatigue and weakness

  • Swollen, bleeding gums

  • Joint pain

• Causes: Insufficient intake of fruits and vegetables, which are primary sources of vitamin C.

6. Iodine Deficiency:

• Symptoms:

  • Goiter (enlarged thyroid gland)

  • Fatigue and weakness

  • Weight gain

• Causes: Inadequate dietary iodine, which is essential for thyroid hormone synthesis.

7. Zinc Deficiency:

• Symptoms:

  • Impaired immune function

  • Delayed wound healing

  • Loss of appetite

• Causes: Inadequate dietary intake, poor absorption, or increased zinc losses.

8. Folate Deficiency:

• Symptoms:

  • Fatigue and weakness

  • Shortness of breath

  • Neural tube defects in pregnancy

• Causes: Inadequate dietary intake, poor absorption, or increased folate needs (pregnancy).

9. Magnesium Deficiency:

• Symptoms:

  • Muscle cramps and spasms

  • Fatigue

  • Irregular heartbeat

• Causes: Inadequate dietary intake, certain medical conditions, or medications that interfere with magnesium absorption.

10. Potassium Deficiency:

• Symptoms:

  • Muscle weakness or cramps

  • Fatigue

  • Irregular heartbeat

• Causes: Inadequate dietary intake, excessive loss (e.g., through vomiting or diarrhea), or certain medications.

It's important to note that symptoms of nutrient deficiencies can vary in severity, and some deficiencies may be asymptomatic in the early stages. If you suspect a deficiency or are experiencing persistent symptoms, it's crucial to consult with a healthcare professional for proper diagnosis and guidance on appropriate interventions, which may include dietary changes or supplement

Unlock Your Full Health Potential

Biohacking isn't just a trend—it's a powerful tool that can help you unlock your fullest health potential. We invite you to embark on this enlightening journey of self-discovery and empowerment through the lens of biohacking. Be sure to listen to the upcoming episode of "M Diva: Biohacking Your Feminine Potential” where I will be discussing all of the above. For the remainder of the year we will be comparing different diets and how they meet the needs of women.

Episode 1: Demystifying Biohacking:

Show transcript:

The Definition and History of Biohacking

Welcome to the inaugural episode of M.D.IVA: Biohacking Your Feminine Potential, where we dive into the fascinating world of biohacking tailored for women. I'm your host, M.D.IVA, and today we're on a mission to unlock the secrets of optimizing women's health through biohacking.

Hello, let's jump right into unraveling the evolution of biohacking and how it can be a transformative tool for optimizing your health and well-being.

For many, biohacking conjures up images of underground labs, citizen scientists, and Silicon Valley tech bros. Then there are those part of a seemingly bizarre subculture of biohacking known as “grinders” that integrate technology and body modification to develop cybernetic organisms, AKA cyborgs. Grinders aim to optimize their body with gadgets and implants that they insert under the skin. It's pretty out there. Some examples, some of you may have heard, and to others, this may be brand new material: There's something called dermal biosensor tattoos that actually change color based on glucose level, pH, and albumin level.

There are RFID implants that are implanted under the skin that can actually unlock your house door, your car door, it can store PINs, you use it to pay for your food, and so forth.

An interesting example I found was artist Neil Harbisson who suffers from a visual condition called achromatopsia or total color blindness. He sees only in shades of gray. So he partnered with some computer scientists in 2003 who created an electronic eye for him. The device that Harbisson wears on his head detects the color frequency of the item that's passed in front of the device, the electronic eye, and it actually turns it into a sound frequency that's passed on to a chip that is installed in the back of Harbisson's head. He then is able to hear the color through bone conduction or sound that travels through the bones of the skull to the inner ear.

He has a fascinating Ted talk that I will link in the show notes that can be found at mdivabiohacking.com.

Back to the term biohacking, it's become much more mainstream. It has evolved into a trendy term to describe optimization or at the most basic level, tweaking your diet, incorporating exercise. Improving your sleep habits, adding supplementation, and other wellness habits in order to, well, optimize one's health, well-being, or overall energy, as well as increase longevity. As a physician, I equate biohacking to the often-used term in medicine, lifestyle modification.

According to the Encyclopedia of Behavior Medicine, lifestyle modification is a behavior intervention that attempts to create change in multiple lifestyle health behaviors. Fun fact, eight of the ten leading causes of death in the U.S. have lifestyle modification as the first line management or even prevention.

Sadiq IZ. Lifestyle medicine as a modality for prevention and management of chronic diseases. J Taibah Univ Med Sci. 2023;18(Issue 5):1115-1117.

So let's take a closer look at the number one cause of death in the US, heart disease.

Heart disease can be further broken down into three categories, arrhythmias, defects, and coronary artery disease. Defects are not what we call a modifiable risk, meaning I can't personally change the defect. But there are known treatments and management for various defects.

However, many arrhythmias causing death can be modified with lifestyle changes, such as limiting your caffeine, abstaining from alcohol and tobacco, reducing stress by incorporating meditation, yoga, and breathing exercises, also managing sleep apnea by losing weight or training oneself to not mouth breathe, and implementing a CPAP if your sleep apnea is resistant to these changes as well as incorporating exercise.

Coronary artery disease is by far the most prevalent form of heart disease and it's almost totally preventable based on lifestyle modification. There are non-modifiable risk factors like age, sex, genetics, and race that increase the likelihood of experiencing heart disease or stroke.

The American College of Cardiology has an atherosclerotic cardiovascular disease or ASCVD risk estimator. This will allow you to enter certain parameters to calculate your risk of heart disease or stroke within the next 10 years. Now what's fun about this calculator, and I kind of laugh at myself when I say what's fun about it because surely I don't think other people necessarily have the same ideal of fun as I do, but in medicine, I happen to think it's really interesting when I can see how lifestyle modifications can change an outcome. So for me, the fun about this calculator is that you can play around by changing some of the modifiable risk factors. It might ask you if you're overweight or if you smoke, if you have hypertension. And if you correct these, it actually shows you the magnitude that small changes can have on your long-term health. This will also be in the show notes, a link to this.

ASCVD Risk Calculator

Now the first line of management of heart disease that is not acute, emergent heart disease or stroke is to correct any reversible risk factors. Quit smoking, vaping, and this includes marijuana. Eat a heart healthy diet, get rid of the processed foods, as well as changing diet, exercise at least 30 minutes, five days a week, maintain a healthy weight with a BMI between 18.5 and 24.9 unless you're an athlete or a bodybuilder. Now someone with high muscle mass, their BMI is not very accurate because it doesn't account for high muscle mass and low body fat.

So we've seen several changes that an individual can make to personally improve their health. And there you go folks, if you're already implementing any of these lifestyle behaviors, you're a biohacker.

And we must agree, biohacking sounds much sexier than lifestyle modification.

I used to live in Grenada, West Indies. And when I would fly into the States, I was always saddened, shocked and saddened. In Grenada, in the airport, the seats were very small. And people from Grenada could fit in them. It was very few people that could not fit in a regular size seat. When I would fly into the United States, I would fly into Miami, and immediately it's like we're in the US because the seats were huge. They were two and three times the size of the seats in Grenada.

And look, I'm not saying this to shame anyone by any means. It's a national issue, and I care. This isn't about being beautiful or not being valued. This is actually about valuing people. I value these individuals that are slowly killing themselves. It is not a one-person issue. This is a national concern that we as a nation really need to start taking seriously. And it's why I'm so passionate about biohacking and modifying what you can in your life. You're the only person who's going to do it. And parents, you're the only one who can do it for your children.

Eighty percent of Americans 20 years and older are overweight or obese. Eight of the 10 leading causes of death have maintain a healthy weight as part of the lifestyle modifications and the management or even prevention of these diseases. You know, most individuals are not adequately counseled by their primary care provider on lifestyle modification.

As a matter of fact, an article in the American Journal of Medicine in 2015 estimated that only 45% of obese patients and 66% of overweight patients are actually informed of their weight status by their primary care providers, much less counseled on diet and exercise.

Now, let me make it clear. Your PCP is drowning. The medical industrial complex wants your doctor to see a different patient every 15 minutes. And that gives very little time for any extensive education. It's much easier to medicate than to educate. Insurance is not going to approve any comprehensive diet, education, or ongoing nutrition counseling, or personal trainers. It's easier and more profitable for all involved EXCEPT THE PATIENT, to keep you alive, but not really living.

I don't know if any of you when you go to the doctor have ever been given one of the patient surveys or they mail it to your house or even call. Well, part of that is that Medicaid and Medicare who are kind of the big guys in insurance, and they have these quality metrics. So they want to know did your doctor do this? Did your doctor do that? How satisfied were you?Your doctor gets scores for this and based on that score it can actually doc his/her pay some. So doctors have learned there are certain topics you just don't really want to bring up to patients because frankly, patients won't give you a very good score and their pay is going to be docked for it.

Say, if I tell you you're overweight, if I tell you you're obese, a lot of people don't want to hear that. They are offended. I have fewer patients who will be upset that I didn't discuss their weight status with them, as opposed to patients who will get very upset if I actually begin to discuss their weight with them. That's really heartbreaking.

This is what happens when businesses are running medicine and not health professionals. You and I are not likely to change this in our lifetime. We can begin a grassroots movement to take a bite out of big pharma and the medical industrial complex by taking control of our health and living our best, healthiest lives.

Biohacking As a Transformative Tool

Let's discuss some of the basics of biohacking and how it can be a transformative tool for optimizing your health. My introduction to biohacking began with the OG of biohacking, the ketogenic diet with intermittent fasting. Now I was a fit teenager. I swam. I did gymnastics. I was very active. When I had my children. I gained a lot of weight. Fortunately, I was able to take it off after each. Now, when I was in my late 20s, I was diagnosed with a serious illness and I began having trouble with anxiety due to the diagnosis. And I was put on a new drug called Paxil and I gained 40 pounds in three months.

We will revisit Paxil and weight gain in another episode. Now, I could not lose the Paxil weight. I did everything I knew to do. I joined all the big commercial plans, no names mentioned, and I followed them to a tee and I would actually gain weight on these plans. I did six small meals throughout the day, low fat with complex carbs, etc, etc. I would work out daily. Nothing helped. Finally, I tried the ketogenic diet with intermittent fasting and the weight fell off. I have maintained my weight for over six years and the only time I've seen an increase in my weight is when I begin to eat more carbs and less healthy fat and meat.

In college, I took four biochemistry courses with each professor stating that the ketogenic diet takes advantage of how our body processes times of famine and times of feast.

Now, needless to say, when I lost the weight and felt better than I had felt in years, I was hooked on biohacking and I wanted to know more. Biohacking can encompass a wide range of practices from optimizing nutrition and exercise to leveraging cutting-edge technologies like wearable devices and genetic testing. It can also involve as I mentioned, intermittent fasting, as well as meditation, specific supplementations that will enhance cognitive function and physical performance. Biohacking is a proactive approach to preventing disease and at its best can further optimize the body. Whereas modern medicine is more reactive by treating symptoms of the body gone wrong.

Biohackers tend to be several steps ahead of modern medicine due to the proverbial 17-year time lag between scientific evidence and clinical practice. Now, what that means is that when science research finds evidence of a new treatment or a possible connection between a behavior, and either a disease getting worse or a behavior in disease actually improving. There's about 17 years before doctors are putting it into practice. Now there's a lot of reasons for this. Insurance companies don't want to cover new treatments.

Refer to Morris ZS, Wooding S, Grant J. The answer is 17 years, what is the question: understanding time lags in translational research. J R Soc Med. 2011 Dec;104(12):510-20. doi: 10.1258/jrsm.2011.110180. PMID: 22179294; PMCID: PMC3241518.

Doctors are also very hesitant or resistant to unlearn outdated practices. And the longer a doctor has been in practice, the greater the resistance.

Refer to Gupta DM, Boland RJ Jr, Aron DC. The physician's experience of changing clinical practice: a struggle to unlearn. Implement Sci. 2017 Feb 28;12(1):28. doi: 10.1186/s13012-017-0555-2. PMID: 28245849; PMCID: PMC5331724.

Taking control of your health through biohacking can result in a vast array of benefits. It can lead to improved energy levels, better mental clarity, enhanced focus, and an even stronger immune system. By understanding our body's unique responses. By tailoring intervention accordingly, we can unlock our full potential and achieve peak performance in various aspects of our lives. While biohacking can offer tremendous benefits, it is essential to approach it with caution. It is crucial to consult with your personal healthcare professional before embarking on any significant biohacking interventions.

Maintaining balance and being mindful of your individual limitations is key to ensuring a safe and effective biohacking journey. For example, this is what not to do. In 2015, I decided I wanted to be a runner. Now let me preface this with, I didn't realize that I could wear costumes during a race and I would get jewelry at the end. Then I found out this little nugget of knowledge and I was like, sign me up, don't mind if you do. However, I was completing my master's thesis in chemistry, to be more exact, my organic synthesis method optimization thesis and I was a tad too busy to train. I am fairly certain that I was so out of shape. I would have become winded running to the mailbox. However, I made the painful mistake of posting my costume on Instagram and making it public knowledge that I was doing the Disney Princess Half Marathon. So pride won and I got up at some god-forsaken hour to ride the monorail with all the other princesses to the start line of this death wish, I mean race.

I did see a girl with a boot on her foot and I thought, if she can do this, I certainly can. All I had to do was an 18-minute mile and not let the balloon people catch me. So at Disney, when you run a race, if you fall behind the 18 minutes per mile, they will give you a balloon and you're out. Well, I just knew I had to stay away from balloon people. When I say that I ran a half marathon, I am using that term very loosely. Crawl would be more accurate. However, I finished. I almost punched the person at the finish line trying to give me my medal because I was certain at that point that I was dying. I have never hurt so bad in my life and I couldn't move for three days. Hence, know your limits.

With that in mind, for those new to biohacking, starting small is often the best approach. First, if you make one change and track that change, you know the effect that change is having. Once you have that habit hammered down, add another. If I had to pick one habit to begin biohacking, it would be sleep optimization. Sleep hygiene is the foundation that all the other habits rest upon.

Tracking your progress using apps and wearable devices can provide valuable insight into how your body responds to different hacks. We cannot stop time, but we now know that we have more control over how we age than we once thought. There are hacks that will help keep you younger, and longer.

This statistic should concern every single listener. The National Center for Health's latest vital statistics reports an overall life expectancy in 2021 of 76.4 years. This is trending down. In 2020, it was 77.0 years. In 2019, it was 78.8 years. From 2014 to 2015, there was a decrease from 78.9 to 78.7. We haven't had strong numbers in almost 10 years. We are number 41 in the world. There are 40 countries with a life expectancy longer than the US life expectancy, even though we are number one in health dollars spent per individual. We spend an average of $12,914 per person per year. Whereas comparable countries spend an average of $6,125 per person per year. So we are spending $6,800 more per person per year and we are number 41. As a nation, we spend $2.3 trillion dollars on healthcare every year with declining outcomes. What a bargain. 2021 Vital Statistics Report

I do have good news. If you dare take control of your personal health, according to a study published in 2018, Harvard T. Chan School of Public Medicine found that lifestyle habits in adulthood may increase life expectancy in women by, are you ready? 14 years! And in men? by 12 years! Men and women who maintained the healthiest lifestyles were 82% less likely to die from cardiovascular disease, and 65% less likely from cancer. What were these low-risk lifestyle factors? Not smoking, low BMI, 18.5 to 24.9, partaking in 30 minutes or more of moderate to vigorous physical activity most days, about five per week. A healthy diet and moderate to no alcohol intake. I would say that these small biohacks are definitely worth incorporating.

“The Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population,” Yanping Li, An Pan, Dong D. Wang, Xiaoran Liu, Klodian Dhana, Oscar H. Franco, Stephen Kaptoge, Emanuele Di Angelantonio, Meir Stampfer, Walter C. Willett, Frank B. Hu, Circulation, April 30, 2018, doi: 10.1161/CIRCULATIONAHA.117.032047

Biohacking Tailored to the Unique Health Needs of Women

We've defined biohacking, discussed the evolution of biohacking into the mainstream, and looked at just how transformative biohacking can be to overall health. Now we'll delve into the realm of biohacking tailored especially for unique health needs and concerns of women. So hop on board, and push that subscribe button, because we're about to embark on a journey to uncover some seriously empowering hacks to help you conquer life's ups and downs without all the unnecessary drama.

While many biohacking practices could benefit everyone, regardless of gender, women have added complexity. We experience puberty, menstrual cycles, pregnancy, breastfeeding, and menopause, all with very different biological needs. For women in their reproductive years, it's all about understanding the intricate dance our hormones love to do month after month.

Women have an infradian rhythm, which is a 28-day cycle on average that regulates a woman's menstrual cycle. It's also referred to as the body's second clock after the 24-hour circadian rhythm. Every day is different and that's why many of us, don't even know which personality we're going to wake up to each day. The infradian rhythm powerfully impacts six systems in women. The brain, metabolism, immune system, microbiome, stress release, and reproductive system. It is beneficial for women to understand how their body and brain will function at different points in their cycle and adopt appropriate diet, exercise, and work patterns that will support their infradian rhythm. As opposed to a same-thing-everyday lifestyle that seems to work well in male physiology. And this is why many more women suffer from hormone-related imbalances than men. Men can benefit from doing the same thing every day, but because our biochemical landscape is constantly changing, something that would suit us in the early follicular phase would stress us in the luteal phase, or during ovulation.

Wikipedia contributors. (2023, November 20). Menstrual cycle. In Wikipedia, The Free Encyclopedia. Retrieved 04:42, November 20, 2023, from https://en.wikipedia.org/w/index.php?title=Menstrual_cycle&oldid=1185963793

When it comes to syncing biohacking with your menstrual cycle, it's all about timing, like planning the ultimate road trip. You want to make sure your body is on board for the journey. If you are practicing intermittent fasting, it's important to time it with your cycle. You'll find yourself often frustrated. Fasting should be for the follicular phase of your cycle which starts on day one of your period and ends at ovulation. Because it's more effective and well, just easier. You'll have more success. And in the luteal phase during ovulation, we need more nutrition, more calories, and more nourishment in general. We're hungry more often, and slightly depressed. And because our amazing bodies are at work building the lining of the uterus known as the endometrium, fasting is biologically counterintuitive. Reserve the feasting or your cheat days for the luteal phase where your body is craving a little extra love and nourishment and chocolate and salt. This is just a summary and there will be an episode dedicated to cycle mapping coming up soon.

Many of us are over-hydrated and dehydrated. Nope, I didn't make a mistake. Overrated while being dehydrated. Overhydration is too much water and it can cause the cells to become underhydrated by flushing out the electrolytes that actually get that water into the cells. By replenishing your electrolytes, you reduce the issue. When over-hydrated, you may notice heart palpitations. Add a tiny pinch of Himalayan pink salt to each glass of water you drink, particularly when working out. And this is also necessary when fasting and in ketosis or on a low-carb diet. When in a ketogenic state, the glucose levels are steady and lower, glucose attracts and holds fluids in the cells. So when in ketosis, you will urinate a lot. This results in a loss of electrolytes. So a pinch of Himalayan pink salt helps to hydrate cells by balancing the electrolytes. It is impactful for health and prevents excessive urination. There are also electrolyte supplements. And as with everything, don't go crazy. FYI, healthy adult kidneys can eliminate up to one liter or 0.2 gallons of water per hour. So don't drink more than your kidneys can eliminate. You can die from over-hydration just as dehydration.

For those of you thinking about embarking on the miraculous journey of motherhood, we will discuss tailored nutrition plans and stress-reducing techniques to help boost your fertility. And for all the women out there who are navigating the roller coaster of menopause, keep that curious mind engaged. My friends, it's your ticket to understanding and embracing the changes gracefully. Remember, each journey is unique. So layering up with practices that nurture both the body and mind is the ultimate key to sailing through these unchartered waters.

An interesting study from 2021 revealed that 73% of women reported that they were not currently treating their menopause symptoms, which include hot flashes, weight gain, difficulties with sleep, and night sweats, among others.

State of Menopause Survey

And a telling study from 2018 showed that nearly 80% of medical residents admit that they felt barely comfortable discussing or treating menopause. Yikes, that's a lot of residents. We will have an entire episode dedicated to menopause and hormone replacement therapy.

In the Misdiagnosis of Menopause, What Needs to Change?

Now it is time for:

Is It BIOHACKING or BIOWHACKING?

Have you ever tried taping your lips at night to promote nostril breathing? Committed mouth tapers claim that mouth taping at night will reduce snoring, improve sleep apnea, and can even change the shape of the face to a more attractive shape, improving the good bacteria in the oral microbiome, therefore decreasing dental caries, aka cavities, and decrease bad breath. Is this a hack or a whack?

I found two studies:

1.    Lee Y C, Lu C T, Cheng W N, Li H Y. The impact of mouth-taping in mouth-breathers with mild obstructive sleep apnea: a preliminary study. Healthcare (Basel) 2022; doi: 10.3390/healthcare10091755. 

2.    Huang T W, Young T H. Novel porous oral patches for patients with mild obstructive sleep apnea and mouth breathing: a pilot study. Otolaryngol Head Neck Surg 2015; 152: 369-373.

Now these are small studies that do support the claims, but proceed with caution. Do not tape your mouth fully closed with duct tape. Simply place a piece of medical-grade tape vertically in the central area of the mouth. Now many mouth-breathers begin taping when awake and train themselves to breathe through the nostrils. The jury's still out, but mouth-breathers swear by it. Let me know what you think by either dropping a comment. I'd love to hear about your experience with this.

Phew, with all this mind-bending info, it's no wonder we've got a whole lineup of episodes dedicated to each of these fantastic topics. Be sure to follow so you do not miss the upcoming episodes and exciting guest appearances from experts who have mastered the art of biohacking.

Before we go, let's not forget the “Holy Trinity of Health” - regular exercise, a balanced diet, and yes, you guessed it, enough sleep with or without tape. We have all heard time and time again that exercise, diet, and sleep are all important for our health. But research now shows that these habits are the best to nail down when it comes to aging well and even reversing your biological age, which is the age at which your cells are aging inside. So incorporating these habits can literally turn back the clock. So while they may sound like old advice, they are the cheapest and most effective ways to optimize health.

Join me on the next episode of M.D.IVA: Biohacking Your Feminine Potential where we will discuss the nutritional needs of women and how they differ from men.

DISCLAIMER: The content provided here is for informational purposes only and is not intended as medical advice. The information shared is not meant to replace professional medical guidance, diagnosis, or treatment. Listeners are encouraged to consult their personal healthcare professionals for advice and treatment plans tailored to their specific needs. The host does not assume any liability for the information provided in this podcast. Any actions taken based on the information presented are at the listener's own risk. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.

A Beginner's Guide To Biohacking for Women":

In the world of wellness and personal optimization, the term "biohacking" has gained significant traction. But what exactly is biohacking, and how can it benefit women on their journey to holistic wellness? In this week’s enlightening episode of "M Diva: Biohacking Your Feminine Potential," we delve into the realm of biohacking through a uniquely female lens, uncovering its transformative potential for women's health and well-being.

Understanding the Basics of Biohacking

Biohacking isn't just a passing trend—it's a powerful approach to enhancing our overall well-being. At its core, biohacking involves understanding the intricacies of the human body and using targeted interventions to optimize its functions. In this article, we explore the fundamental principles that underpin the concept of biohacking and examine how it can revolutionize the way women approach their health and performance. The first line of treatment for most chronic diseases is lifestyle modification. Biohacking can be thought of as a buzzword for lifestyle modification.

Tailoring Biohacking for Women's Health

Recognizing the unique aspects of female biology and physiology is crucial when implementing biohacking practices. Hormonal fluctuations and the menstrual cycle play a significant role in how women can effectively harness the power of biohacking from what type of exercise will result in optimal outcomes based on infradian rhythm to thriving during menopause. We delve into how understanding these factors can help tailor biohacking techniques specifically for women, ensuring they optimize their health in the most effective way possible.

Essential Biohacking Techniques for Women

From personalized nutrition plans to targeted supplementation and mindful lifestyle adjustments, we uncover some essential biohacking techniques that can be seamlessly integrated into the lives of busy women. These techniques hold the key to unlocking a world of energy, mental clarity, and emotional well-being for women from all walks of life.

Implementing Biohacking in Daily Life

As we conclude this episode, we discuss practical tips for seamlessly integrating biohacking practices into your daily routine. Small, sustainable steps can make a significant difference, and setting achievable goals and tracking your progress can help you monitor the impact of biohacking on your overall health and wellness.

Unlock Your Full Health Potential

Biohacking isn't just a trend—it's a powerful tool that can help you unlock your fullest health potential. We invite you to embark on this enlightening journey of self-discovery and empowerment through the lens of biohacking. Stay tuned for more insights and practical strategies in the upcoming episodes of "M Diva: Biohacking Your Feminine Potential."